The NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ mice, commonly known as NOD scid gamma (NSG), do not express the Prkdc gene nor the X-linked Il2rg gene. NSG mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Histological examination of lymphoid tissues reveals absence of lymphoid cells and some cystic structures in the thymus, an absence of follicles in the spleen and markedly diminished celluarity of lymph nodes. NSG mice are deficient in mature lymphocytes, serum Ig is not detectable and natural killer (NK) cell cytotoxic activity is extremely low. These mice are resistant to lymphoma development even after sublethal irradiation treatment. These mutant mice have been shown to readily support engraftment of human CD34+ hematopoietic stem cells and represent a superior, long-lived model suitable for studies employing xenotransplantation strategies. Please note that the NSG carries the true null interleukin-2 receptor gamma chain mutation and should not be confused with other strains that express a truncated interleukin-2 receptor gamma chain as described in: "Modulation of hematopoiesis in mice with a truncated mutant of the interleukin-2 receptor gamma chain" Ohbo K et al. Blood 1996. 87:956-67.
- Tumor Models (W420)
- DKFZ (German Cancer Research Center)
- Priv. Doz. Dr. Karin Müller-Decker
- 5/21/2015 1:22:40 PM
- 7/7/2016 2:58:06 PM
This animal line is used as experimental line in
Orthotopic MCF7 breast adenocarcinoma (NOD-SCID gamma)
Description orthotopic transplantation into estrogen supplemented NOD-SCID gamma female mice in growth factor-reduced Matrigel
Triple negative human breast cancer SUM 149
Description SUM 149 triple negative human breast cancer tumors after orthotopic transplantation into NSG mice
BxPC-3 pancreatic adenocarcinoma transplantation (ectopic)
Description Subcutaneous heterotransplantation of BxPC-3 cells into NSG mice
HH cutaneous T-cell lymphoma (orthotopic)
Description The model has been shown to be suitable for testing of small inhibitors such as dimethylfumarate (DMF) and SAHA. HH are commercially available from ATCC.
HH cutaneous T-cell lymphoma (subcutaneous)
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