animal line from the MiTO database, mito.dkfz.de
Organism picture
K14 38/187
Mouse (Mus musculus)
Mutagenesis approach Gene name (donor species) Regulatory element (donor species) Modification of gene activity Expressed in organ/celltypes
genetically modified
E6 and E7 (HPV38)
Keratin 14 promoter (Homo sapiens) conditionally inducible inactivation forestomach/basal keratinocyte;
esophagus/basal keratinocyte;
tongue/basal keratinocyte;
skin/basal keratinocyte;
  • Increased proliferation of keratinocytes in skin epithelium

  • The viral proteins E6 and E7 from HPV38 are expressed in proliferating epithelia

  • This mouse is transgenic for the early genes E6 and E7 from the cutaneous papillomavirus type 38 and is used to study the role of HPV infection in skin carcinogenesis and skin carcinogenesis in general. The two viral proteins are expressed in the epithelia of the mouse since they are under the control of a keratin 14 promoter: the viral mRNA has been clearly detected in the skin, in the tongues tissue and in the oesophagus of the mice The animals do not show any spontaneous phenotype that can be linked to the presence to the transgenes.

Available at

  • Molecular Diagnostics of Oncogenic Infections (F020)
  • DKFZ (German Cancer Research Center)
  • Daniele Viarisio
  • 5/28/2015 1:40:55 PM
  • 7/7/2016 2:58:06 PM
  • Original

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