|Mutagenesis approach||Gene name (donor species)||Regulatory element (donor species)||Modification of gene activity||Expressed in organ/celltypes|
E6 and E7 (HPV38)
|Keratin 14 promoter (Homo sapiens)||conditionally inducible inactivation||
Increased proliferation of keratinocytes in skin epithelium
The viral proteins E6 and E7 from HPV38 are expressed in proliferating epithelia
This mouse is transgenic for the early genes E6 and E7 from the cutaneous papillomavirus type 38 and is used to study the role of HPV infection in skin carcinogenesis and skin carcinogenesis in general. The two viral proteins are expressed in the epithelia of the mouse since they are under the control of a keratin 14 promoter: the viral mRNA has been clearly detected in the skin, in the tongues tissue and in the oesophagus of the mice The animals do not show any spontaneous phenotype that can be linked to the presence to the transgenes.
- Molecular Diagnostics of Oncogenic Infections (F020)
- DKFZ (German Cancer Research Center)
- Daniele Viarisio
- 5/28/2015 1:40:55 PM
- 7/7/2016 2:58:06 PM
This animal line is used as experimental line in
Upper digestive tract cancer and Human Papillomavirus
Skin cancer and Human Papillomavirus
Description Using the mouse line indicated, we have developed a tumour model in which we are able to reproducibly induce skin carcinogenesis using chemical carcinogens or chronic exposure to ultraviolet light. In particular, irradiating the mice with UV-B leads to a carcinogenesis process that closely resembles the stages observed in humans. This model is therefore suitable to study skin cancer in general and the contribution of the HPV genes to the process.
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