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Upper digestive tract cancer and Human Papillomavirus
preclinical tumor model from the MiTO database
https://mito.dkfz.de/mito/TumorModel/10635
  • HPV 4-NQO Tongue cancer esophageal cancer


Manipulations and tumor entities

    • When the mice are fed with the following amount of carcinogen they show a tumor incidence in the upper digestive tract of 80%, significantly higher than what observed in wild type mice (10% incidence)

    • 4-NQO is dissolved in water containing 1% of 1,2 propylene-glycol (PPG) to a final concentration of 10ug/ml

    • 6-week-old mice are given water containing 4-NQO for 16 weeks. After this period, the mice receive normal water again.

    • The mice are sacrificed when they show a weight loss for two consecutive measurement (2 measurement/week) or latest 30 weeks after the beginning of the experiment. The tumor incidence at the end of the experiment is roughly 80%, the SCC incidence at the end of the experiment is roughly 60%. In a single mouse more lesions are normally recorded. This line shows a behaviour very close to the HPV16 E6/E7 transgenic mice, indicating a potential role for HPV49 in upper digestive tract carcinogenesis.

    • Squamous cell carcinoma and papillomas

    • well-differentiated

    • basal epithelial cell

    • Tongue, esophagus, forestomach

    • When the mice are fed with the following amount of carcinogen they show a tumor incidence in the upper digestive tract of 80%, significantly higher than what observed in wild type mice (10% incidence)

    • 4-NQO is dissolved in water containing 1% of 1,2 propylene-glycol (PPG) to a final concentration of 10ug/ml

    • 6-week-old mice are given water containing 4-NQO for 16 weeks. After this period, the mice receive normal water again.

    • The mice are sacrificed when they show a weight loss for two consecutive measurement (2 measurement/week) or latest 30 weeks after the beginning of the experiment. The tumor incidence at the end of the experiment is roughly 80%, the SCC incidence at the end of the experiment is roughly 60%. In a single mouse more lesions are normally recorded.

    • Squamous cell carcinomas and papillomas

    • well-differentiated

    • basal epithelial cells

    • Tongue, esophagus, forestomach

    • When the mice are fed with the following amount of carcinogen they show a tumor incidence in the upper digestive tract of 40%, higher than what observed in wild type mice (15% incidence)

    • 4-NQO is dissolved in water containing 1% of 1,2 propylene-glycol (PPG) to a final concentration of 10ug/ml

    • 6-week-old mice are given water containing 4-NQO for 16 weeks. After this period, the mice receive normal water again.

    • The mice are sacrificed when they show a weight loss for two consecutive measurement (2 measurement/week) or latest 30 weeks after the beginning of the experiment. The tumor incidence at the end of the experiment is roughly 40%, No SCC were recorded during the whole experiment. Within the three lines examined, this one shows a behaviour quite close to wild type mice.

    • Papillomas, benign lesiosn

    • well-differentiated

    • basal epithelial cells

    • Tongue, esophagus


Available at

  • Molecular Diagnostics of Oncogenic Infections (F020)
  • DKFZ (German Cancer Research Center)
  • Daniele Viarisio
  • 3/22/2017 1:35:01 PM
  • 3/22/2017 3:04:05 PM
  • Original

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