Syngeneic transplantation of 4T1 cells into Balb/cN mice. Resection of primary tumor and follow-up of metastasis to lungs
- metastasis 4t1 syngeneic mammary gland tumor breast cancer model lymphnode metastasis
Experimental animal and cell lines used
Manipulations and tumor entities
mammary tumor cell
40000 cells/30 µl PBS
primary mammary gland tumor growth after 8 days of latency. Resection of primary tumors 11 days post transplantation at a mean tumor volume of 0,134 cm³. Pain management with Metamizol: 200 mg/kg s.c. 20 min prior to surgery and thereafter via 800 mg/kg in drinking water.
21 days post resection, the lungs were positive for macroscopically visible lung metastasis. Lymph nodes were positive on the flank with surgery.
100 % take-rate of primary tumors and lung metastasis
mammary gland tumor
mammary gland tumor cell
Rios-Garcia Marcos et al. Cell Metabolism 2017...
- Tumor Models (W420)
- DKFZ (German Cancer Research Center)
- Priv. Doz. Dr. Karin Müller-Decker
- 10/5/2017 11:08:20 AM
- 3/20/2018 5:49:40 PM
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