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Postsurgical 4T1 metastasis model
preclinical tumor model from the MiTO database
https://mito.dkfz.de/mito/TumorModel/10645
  • Syngeneic transplantation of 4T1 cells into Balb/cN mice. Resection of primary tumor and follow-up of metastasis to lungs

  • metastasis 4t1 syngeneic mammary gland tumor breast cancer model lymphnode metastasis


Manipulations and tumor entities

    • mammary tumor cell

    • 40000 cells/30 µl PBS

    • orthotopically

    • primary mammary gland tumor growth after 8 days of latency. Resection of primary tumors 11 days post transplantation at a mean tumor volume of 0,134 cm³. Pain management with Metamizol: 200 mg/kg s.c. 20 min prior to surgery and thereafter via 800 mg/kg in drinking water.

      21 days post resection, the lungs were positive for macroscopically visible lung metastasis. Lymph nodes were positive on the flank with surgery.

    • 100 % take-rate of primary tumors and lung metastasis

    • mammary gland tumor

    • mammary gland tumor cell

    • mammary gland


  • Rios-Garcia Marcos et al. Cell Metabolism 2017...

Available at

  • Tumor Models (W420)
  • DKFZ (German Cancer Research Center)
  • Priv. Doz. Dr. Karin Müller-Decker
  • 10/5/2017 11:08:20 AM
  • 3/20/2018 5:49:40 PM
  • Original

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